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PF-1355

CAS No. 1435467-38-1

PF-1355 ( PF-06281355; PF 06281355; ZINC205721785 )

Catalog No. M28021 CAS No. 1435467-38-1

PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-1355
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
  • Description
    PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.(In Vitro):PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM) .(In Vivo):Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment .
  • Synonyms
    PF-06281355; PF 06281355; ZINC205721785
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1435467-38-1
  • Formula Weight
    321.4
  • Molecular Formula
    C14H15N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C=C(C=2C=C(OC)C=CC2OC)N(C(=S)N1)CC(=O)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Prats E, et al. Antifungal activity of a new phenolic compound from capitulum of a head rot-resistant sunflower genotype. J Chem Ecol.?2007 Dec;33(12):2245-53. Epub 2007 Nov 22.
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