SH-42( —— )

Catalog No. M34858 CAS No. 2143952-36-5

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

SH-42
Note

Research use only, not for human use.
Brief Description

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.
Description

SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

2143952-36-5
Formula Weight

402.57
Molecular Formula

C25H38O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 2 mg/mL (4.97 mM; Ultrasonic (<60°C)
SMILES

C[C@@]12[C@@]3(C([C@]4([C@](C)(CC3)[C@@]([C@@H](COC=O)C)(CC4)[H])[H])=CC[C@]1(C[C@@H](OC(C)=O)CC2)[H])[H]
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320.?

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