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BR102910?

CAS No. 2505339-54-6

BR102910?( 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]- )

Catalog No. M28937 CAS No. 2505339-54-6

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-(BR102910) is a selective inhibitor of fibroblast activated protein (FAP).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BR102910?
  • Note
    Research use only, not for human use.
  • Brief Description
    4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-(BR102910) is a selective inhibitor of fibroblast activated protein (FAP).
  • Description
    4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-(BR102910) is a selective inhibitor of fibroblast activated protein (FAP).(In Vivo):4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-(C57BL/6J mice, 0-30 mg/kg, orally, once) showed significant FAP inhibition in a dose dependent manner .
  • In Vitro
    ——
  • In Vivo
    BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner. Animal Model:C57BL/6J mice (n = 5 per group)Dosage:0, 10 and 30 mg/kg Administration:Orally, once Result:Showed significant FAP inhibition in a dose dependent manner.
  • Synonyms
    4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2505339-54-6
  • Formula Weight
    459.3
  • Molecular Formula
    C18H14Cl2F2N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (217.72 mM)
  • SMILES
    O=C(C1=CSC(CC2=CC=C(Cl)C(Cl)=C2)=N1)NCC(N3[C@@H](C#N)CC(F)(F)C3)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang GR, et al. New flavonoids with 2BS cell proliferation promoting effect from the seeds of Trigonella foenum-graecum L. J Nat Med. 2010 Jul;64(3):358-61.
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