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SGC-GAK-1

CAS No. 2226517-76-4

SGC-GAK-1( —— )

Catalog No. M19961 CAS No. 2226517-76-4

SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SGC-GAK-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
  • Description
    SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
  • In Vitro
    Cell Viability Assay Cell Line:Prostate cancer cells (22Rv1, LNCaP, VCaP, PC3, DU145) Concentration:0.1, 1, and 10 μM Incubation Time:48 hours or 72 hours Result:Showed potent antiproliferative activity in LNCaP and 22Rv1 cells with IC50s of 0.05±0.15 μM and 0.17±0.65 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2226517-76-4
  • Formula Weight
    389.24
  • Molecular Formula
    C18H17BrN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 40 mg/mL;Ethanol: 15 mg/mL
  • SMILES
    COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC
  • Chemical Name
    6-Bromo-N-(345-trimethoxyphenyl)quinolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Asquith CRM et al. SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem. 2019 Feb 26.
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