
SETDB1-TTD-IN-1
CAS No. 2755823-12-0
SETDB1-TTD-IN-1( —— )
Catalog No. M28873 CAS No. 2755823-12-0
SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 599 | Get Quote |
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10MG | 853 | Get Quote |
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25MG | 1278 | Get Quote |
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50MG | 1701 | Get Quote |
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100MG | 2313 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameSETDB1-TTD-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionSETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
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DescriptionSETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.(In Vitro):SETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells. SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells. SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with Kds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (Kd>100 μM).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorFusion protein|RSV
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Research Area——
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Indication——
Chemical Information
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CAS Number2755823-12-0
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Formula Weight469.58
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Molecular FormulaC28H31N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (266.20 mM)
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SMILESCN1C[C@H](C[C@H](C1)NC2=NC3=C(NC=C3)C(N2CC=C)=O)C4=CC=C(C=C4)OCC5=CC=CC=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Roymans D, et al. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat Commun. 2017 Aug 1;8(1):167.
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