GSK-467( GSK467 )

Catalog No. M12429 CAS No. 1628332-52-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

GSK-467
Note

Research use only, not for human use.
Brief Description

GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM.
Description

GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members; increases the rate of apoptosis in myeloma cells.
In Vitro

Cell Proliferation Assay Cell Line:Human multiple myeloma tumor cell line MM.1S Concentration:0-100 μM Incubation Time:6 days Result:Showed antiproliferative effect with an IC50 of >50 μM.
In Vivo

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Synonyms

GSK467
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

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Indication

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CAS Number

1628332-52-4
Formula Weight

319.32
Molecular Formula

C17H13N5O2
Purity

>98% (HPLC)
Solubility

DMSO : 20.83 mg/mL 65.23 mM; H2O : < 0.1 mg/mL
SMILES

O=C1C2=C(C=NC=C2)N=C(OC3=CN(CC4=CC=CC=C4)N=C3)N1
Chemical Name

2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45. 2. Westaway SM, et al. J Med Chem. 2016 Feb 25;59(4):1370-87.

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