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GSK-467
CAS No. 1628332-52-4
GSK-467( GSK467 )
Catalog No. M12429 CAS No. 1628332-52-4
GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 160 | Get Quote |
|
| 10MG | 237 | Get Quote |
|
| 25MG | 475 | Get Quote |
|
| 50MG | 689 | Get Quote |
|
| 100MG | 963 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
| 1 mL x 10 mM in DMSO | 187 | Get Quote |
|
| 5MG | 144 | Get Quote |
|
| 10MG | 218 | Get Quote |
|
| 25MG | 405 | Get Quote |
|
| 50MG | 616 | Get Quote |
|
| 100MG | 830 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK-467
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM.
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DescriptionGSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members; increases the rate of apoptosis in myeloma cells.
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In VitroCell Proliferation Assay Cell Line:Human multiple myeloma tumor cell line MM.1S Concentration:0-100 μM Incubation Time:6 days Result:Showed antiproliferative effect with an IC50 of >50 μM.
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In Vivo——
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SynonymsGSK467
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorHistone Demethylase
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Research Area——
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Indication——
Chemical Information
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CAS Number1628332-52-4
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Formula Weight319.32
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Molecular FormulaC17H13N5O2
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Purity>98% (HPLC)
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SolubilityDMSO : 20.83 mg/mL 65.23 mM; H2O : < 0.1 mg/mL
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SMILESO=C1C2=C(C=NC=C2)N=C(OC3=CN(CC4=CC=CC=C4)N=C3)N1
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Chemical Name2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.
2. Westaway SM, et al. J Med Chem. 2016 Feb 25;59(4):1370-87.
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