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Home - Products - GPCR/G Protein - Cannabinoid Receptor - SCH-336

SCH-336

CAS No. 447459-51-0

SCH-336( —— )

Catalog No. M34024 CAS No. 447459-51-0

SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 46 Get Quote
5MG 69 Get Quote
10MG 112 Get Quote
25MG 251 Get Quote
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Biological Information

  • Product Name
    SCH-336
  • Note
    Research use only, not for human use.
  • Brief Description
    SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1.
  • Description
    SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice.
  • In Vitro
    SCH 336 (Sch.336) (0-10 μM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Ki of 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50 of 2 nM, decreases potency on CB1-containing membranes with EC50 of 200 nM.SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50 of 34 nM.
  • In Vivo
    SCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes.Animal Model:Female B6D2/F1 mice (HU210) Dosage:0.02, 0.2, 2.0 mg/kg Administration:I.p.Result:Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Cannabinoid Receptor
  • Recptor
    Cannabinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    447459-51-0
  • Formula Weight
    539.64
  • Molecular Formula
    C23H25NO8S3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (185.31 mM; Ultrasonic )
  • SMILES
    S(=O)(=O)(C1=C(S(=O)(=O)C2=CC=C(OC)C=C2)C=C(OC)C=C1)C3=CC=C([C@@H](NS(C)(=O)=O)C)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lunn CA, et al. A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther. 2006 Feb;316(2):780-8.?
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