
SC144
CAS No. 895158-95-9
SC144( —— )
Catalog No. M17647 CAS No. 895158-95-9
SC144 is an orally active small-molecule gp130 inhibitor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 35 | In Stock |
![]() ![]() |
10MG | 61 | In Stock |
![]() ![]() |
25MG | 125 | In Stock |
![]() ![]() |
50MG | 210 | In Stock |
![]() ![]() |
100MG | 353 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameSC144
-
NoteResearch use only, not for human use.
-
Brief DescriptionSC144 is an orally active small-molecule gp130 inhibitor.
-
DescriptionSC144 is an orally active small-molecule gp130 inhibitor.
-
In VitroSC144 inhibits cell growth in a panel of human ovarian cancer cell lines with IC50s in a submicromolar range (IC50=OVCAR-8, OVCAR-5, OVCAR-3= 0.72, 0.49, 0.95 μM).The potency of SC144 toward NCI/ADR-RES (Paclitaxel- and Doxorubicin-resistant, IC50=0.43 μM) and HEY (Cisplatin-resistant, IC50=0.88 μM) suggests an ability to overcome drug resistance in ovarian cancer.SC144 (2 μM; 24 hours) causes significantly more apoptosis in OVCAR-8 and Caov-3 than normal kidney epithelial and normal endometrial cells.SC144 (0.5-2 μM; 0-6 hours) substantially increases the phosphorylation of gp130 (S782) in both OVCAR-8 and Caov-3 cells in a time- and dose-dependent manner.SC144 is cytotoxic to ovarian cancer cells via a mechanism involving the inhibition of gp130 activity, leading to the inactivation of Akt and Stat3 as well as the suppression of Stat3-regulated gene expression. As are result, SC144 treatment eventually causes cell-cycle arrest, anti-angiogenesis, and apoptosis. Apoptosis Analysis Cell Line:OVCAR-8 and Caov-3 cells Concentration:2 μM Incubation Time:24 hours Result:Significantly caused cell death in OVCAR-8 and Caov-3 cells.Western Blot Analysis Cell Line:OVCAR-8, Caov-3 cells Concentration:0.5-2 μM Incubation Time:0-6 hours Result:Substantially increased the phosphorylation of gp130 (S782) in both OVCAR-8 and Caov-3 cellsin a time- and dose-dependent manner.
-
In VivoSC144 (10 mg/kg; i.p.; daily for 58 days) suppresses tumor growth in human ovariancancer xenografts.SC144 (100 mg/kg;p.o.; daily for 35 days) treatment shows the average tumor volume in mice 82% smaller than that in the control group. Animal Model:Athymic mice (human ovarian cancer xenograft)Dosage:10 mg/kg Administration:I.p; daily for 58 days Result:Significantly inhibited tumor growth by about 73%.
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetDNA/RNA Synthesis
-
Recptorgp130
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number895158-95-9
-
Formula Weight322.3
-
Molecular FormulaC16H11FN6O
-
Purity>98% (HPLC)
-
SolubilityDMSO : 19.5 mg/mL. 60.50 mM;
-
SMILESFc1cc2c(cc1)n1cccc1c(NNC(=O)c1cnccn1)n2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Oshima T, et al. Anticancer Drugs, 2009, 20(5), 312-320.
molnova catalog



related products
-
L82-G17
L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
-
5-Fluorouridine
5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid.
-
TH-287
A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM.