SC-202671

CAS No. 312917-14-9

SC-202671 ( TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671 )

Catalog No. M18411 CAS No. 312917-14-9

TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 35 In Stock
10MG 58 In Stock
25MG 104 In Stock
50MG 177 In Stock
100MG 267 In Stock
500MG 655 In Stock
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Biological Information

  • Product Name
    SC-202671
  • Note
    Research use only, not for human use.
  • Brief Description
    TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
  • Description
    TCS JNK 5a, also called JNK Inhibitor IX , is a selective and potent inhibitor of JNK inhibitor. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase cascade.
  • Synonyms
    TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    JNK2; JNK3
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    312917-14-9
  • Formula Weight
    332.42
  • Molecular Formula
    C20H16N2OS
  • Purity
    98%
  • Solubility
    DMSO : ≥ 51 mg/mL; 153.42 mM
  • SMILES
    C1CCc2c(C1)c(c(s2)NC(=O)c1cccc2ccccc12)C#N
  • Chemical Name
    N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Angell RM, et al. Bioorg Med Chem Lett. 2007, 17(5), 1296-1301.2. Rudolf E, et al. Toxicol Lett. 2009, 188(3), 236-242.
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