SC-202671( TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671 )

Catalog No. M18411 CAS No. 312917-14-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SC-202671
Note

Research use only, not for human use.
Brief Description

TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
Description

TCS JNK 5a, also called JNK Inhibitor IX , is a selective and potent inhibitor of JNK inhibitor. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase cascade.
In Vitro

TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them.
In Vivo

——
Synonyms

TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671
Pathway

Others
Target

Other Targets
Recptor

JNK2| JNK3
Research Area

Inflammation/Immunology
Indication

——

CAS Number

312917-14-9
Formula Weight

332.42
Molecular Formula

C20H16N2OS
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 51 mg/mL; 153.42 mM
SMILES

C1CCc2c(C1)c(c(s2)NC(=O)c1cccc2ccccc12)C#N
Chemical Name

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide

1. Angell RM, et al. Bioorg Med Chem Lett. 2007, 17(5), 1296-1301.2. Rudolf E, et al. Toxicol Lett. 2009, 188(3), 236-242.

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