SB366791

Research use only, not for human use.

SB-366791 is a new and selective cinnamide TRPV1 antagonist.

SB-366791is a potent and selective TRPV1 antagonist. SB-366791 inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. SB-366791 decreased capsaicin-induced Ca2+ influx in cultured trigeminal ganglion cells in a concentration-dependent manner (0.5-10 microM) with an IC50 of 651.9 nM. SB366791 is a more selective and in vivo also a more potent TRPV1 receptor antagonist than capsazepine in the rat therefore, it may promote the assessment of the therapeutic utility of TRPV1 channel blockers.

SB-366791; SB 366791; SB366791

Others

Other Targets

TRPV1

Cancer

——

472981-92-3

287.74

C16H14ClNO2

98%

DMSO : ≥ 39 mg/mL 135.54 mM; H2O : < 0.1 mg/mL

COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl

3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide

(-20℃)

With Ice Pack

≥ 2 years