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SB-705498
CAS No. 501951-42-4
SB-705498 ( SB 705498;SB705498 )
Catalog No. M14693 CAS No. 501951-42-4
A potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 61 | In Stock |
|
| 10MG | 113 | In Stock |
|
| 25MG | 264 | In Stock |
|
| 50MG | 478 | In Stock |
|
| 100MG | 691 | In Stock |
|
| 500MG | 1422 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB-705498
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
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DescriptionA potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor); causes rapid and reversible inhibition of the capsaicin (IC50=3 nM), acid (pH 5.3), or heat (50 degrees C; IC50=6 nM)-mediated activation of human TRPV1 (at -70 mV).Pain Phase 1 Discontinued
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SynonymsSB 705498;SB705498
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorhTRPV1
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number501951-42-4
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Formula Weight429.23
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Molecular FormulaC17H16BrF3N4O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N[C@H]1CN(C2=NC=C(C(F)(F)F)C=C2)CC1)NC3=CC=CC=C3Br
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Chemical NameUrea, N-(2-bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rami HK, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3287-91.
2. Gunthorpe MJ, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1183-92.
3. Chizh BA, et al. Pain. 2007 Nov;132(1-2):132-41.
2. Gunthorpe MJ, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1183-92.
3. Chizh BA, et al. Pain. 2007 Nov;132(1-2):132-41.
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