Berbamine

Research use only, not for human use.

Berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII.

Berbamine has high binding affinity toward the (GGA);G-quadruplex. Berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII. Berbamine may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia. 4. Berbamine can enhance the antitumor activity of gemcitabine by inhibiting cell growth and inducing apoptosis, possibly through the regulation of the expression of apoptosis-related proteins and the activation of TGF-β/Smad signaling pathway. Berbamine confers cardioprotection against I/R injury by attenuating [Ca(2+)inf(i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK(ATP) channel.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

CAMKIIγ

Cancer

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478-61-5

608.73

C37H40N2O6

98%

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CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC

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(-20℃)

With Ice Pack

≥ 2 years