SAR-100842 ( SAR100842 )

Catalog No. M10688 CAS No. 1195941-38-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SAR-100842
Note

Research use only, not for human use.
Brief Description

SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.
Description

SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays; demonstrates potential for the treatment of systemic sclerosis and related fibrotic diseases.Other Indication Phase 2 Discontinued
Synonyms

SAR100842
Pathway

GPCR/G Protein
Target

Lysophospholipid Receptor
Recptor

Edg-2receptor
Research Area

Other Indications
Indication

Other Disease

CAS Number

1195941-38-8
Formula Weight

445.52
Molecular Formula

C27H27NO5
Purity

>98% (HPLC)
Solubility

DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(C1(NC(C2=CC=C(OC)C(OCCC3=CC=CC(C)=C3)=C2)=O)CC4=C(C=CC=C4)C1)O
Chemical Name

2-{4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzamido}-2,3-dihydro-1H-indene-2-carboxylic acid

1. Ellery J, et al. Eur J Pharmacol. 2018 May 26;833:8-15.
2. Kihara Y, et al. Exp Cell Res. 2015 May 1;333(2):171-7.

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