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SANT-1

CAS No. 304909-07-7

SANT-1( SANT-1 | SANT 1 | SANT1 )

Catalog No. M13967 CAS No. 304909-07-7

SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 43 In Stock
10MG 69 In Stock
25MG 115 In Stock
50MG 186 In Stock
100MG 332 In Stock
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Biological Information

  • Product Name
    SANT-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
  • Description
    SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
  • In Vitro
    Cell Viability Assay Cell Line:Medulloblastoma cells Concentration:1 μM Incubation Time:24 hours or 48 hours Result:Inhibited cellular proliferation in primary tumorspheres.
  • In Vivo
    ——
  • Synonyms
    SANT-1 | SANT 1 | SANT1
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Smoothened
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    304909-07-7
  • Formula Weight
    373.49
  • Molecular Formula
    C23H27N5
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 20 mg/mL (53.54 mM); DMSO: 21 mg/mL (56.22 mM)
  • SMILES
    CC1=C(/C=N/N2CCN(CC3=CC=CC=C3)CC2)C(C)=NN1C4=CC=CC=C4
  • Chemical Name
    N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. James K. Chen, et al. Proc natl Acad Sci U S A, 2002, 99(22), 14071-14076.
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