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Navitoclax

CAS No. 923564-51-6

Navitoclax( ABT-263 | ABT 263 | ABT263 )

Catalog No. M16614 CAS No. 923564-51-6

Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 46 In Stock
5MG 37 In Stock
10MG 51 In Stock
25MG 80 In Stock
50MG 131 In Stock
100MG 174 In Stock
200MG 299 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Navitoclax
  • Note
    Research use only, not for human use.
  • Brief Description
    Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.
  • Description
    Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w; binds more weakly to Mcl-1 and A1 (Ki>350 nM); disrupts Bcl-2/Bcl-xL interactions with pro-death proteins (e.g., Bim), induces apoptosis, shows cellular activity against a panel of human tumor cell lines (EC50<1 uM); induces complete tumor regressions in xenograft models of NSCLA and ALL.Blood Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Mice with NCI-H1650 modelDosage:100 mg/kg Administration:Orally; daily; for 21 consecutive days Result:As a single agent, 100 mg/kg alone dosed daily had no significant antitumor activity. Notably, the combination with OSI-744 resulted in 98% TGI and durable tumor regressions in 100% of treated tumor-bearing mice.
  • Synonyms
    ABT-263 | ABT 263 | ABT263
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2|Bcl-w|Bcl-xL
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    923564-51-6
  • Formula Weight
    974.6127
  • Molecular Formula
    C47H55ClF3N5O6S3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NS(=O)(C1=CC=C(N[C@H](CCN2CCOCC2)CSC3=CC=CC=C3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4
  • Chemical Name
    Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tse C, et al. Cancer Res. 2008 May 1;68(9):3421-8. 2. Shoemaker AR, et al. Clin Cancer Res. 2008 Jun 1;14(11):3268-77. 3. Ackler S, et al. Mol Cancer Ther. 2008 Oct;7(10):3265-74. 4. Shah OJ, et al. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12634-9.
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