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Roscovitine
CAS No. 186692-46-6
Roscovitine ( CYC-202;CYC 202;CYC202;Seliciclib )
Catalog No. M12883 CAS No. 186692-46-6
A potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 36 | In Stock |
|
| 10MG | 45 | In Stock |
|
| 25MG | 92 | In Stock |
|
| 50MG | 116 | In Stock |
|
| 100MG | 155 | In Stock |
|
| 200MG | 213 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRoscovitine
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively.
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DescriptionA potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively; weakly inhibits ERK1 and ERK2 (IC50=34 uM and 14 uM), poorly inhibits CDK4/cyclin D1 and CDK6/cyclin D2 (IC50>100 uM); suppresses the proliferation of mammalian cell lines with an average IC50 of 16 uM; significantly inhibits growth of The Ewing's sarcoma family of tumors (ESFT) xenografts.Lung Cancer Phase 2 Clinical
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SynonymsCYC-202;CYC 202;CYC202;Seliciclib
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PathwayAngiogenesis
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TargetCDK
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RecptorCdc2/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK5/p35;ERK2
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number186692-46-6
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Formula Weight354.45
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Molecular FormulaC19H26N6O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC[C@@H](NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
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Chemical Name1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Meijer L, et al. Eur J Biochem. 1997 Jan 15;243(1-2):527-36.
2. Tirado OM, et al. Cancer Res, 2005, 65(20), 9320-9327.
3. Mgbonyebi OP, et al. Cancer Res. 1999 Apr 15;59(8):1903-10.
2. Tirado OM, et al. Cancer Res, 2005, 65(20), 9320-9327.
3. Mgbonyebi OP, et al. Cancer Res. 1999 Apr 15;59(8):1903-10.
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