Roscovitine

CAS No. 186692-46-6

Roscovitine ( CYC-202;CYC 202;CYC202;Seliciclib )

Catalog No. M12883 CAS No. 186692-46-6

A potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 36 In Stock
10MG 45 In Stock
25MG 92 In Stock
50MG 116 In Stock
100MG 155 In Stock
200MG 213 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Roscovitine
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively.
  • Description
    A potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively; weakly inhibits ERK1 and ERK2 (IC50=34 uM and 14 uM), poorly inhibits CDK4/cyclin D1 and CDK6/cyclin D2 (IC50>100 uM); suppresses the proliferation of mammalian cell lines with an average IC50 of 16 uM; significantly inhibits growth of The Ewing's sarcoma family of tumors (ESFT) xenografts.Lung Cancer Phase 2 Clinical
  • Synonyms
    CYC-202;CYC 202;CYC202;Seliciclib
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Cdc2/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK5/p35;ERK2
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    186692-46-6
  • Formula Weight
    354.45
  • Molecular Formula
    C19H26N6O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC[C@@H](NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
  • Chemical Name
    1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Meijer L, et al. Eur J Biochem. 1997 Jan 15;243(1-2):527-36.
2. Tirado OM, et al. Cancer Res, 2005, 65(20), 9320-9327.
3. Mgbonyebi OP, et al. Cancer Res. 1999 Apr 15;59(8):1903-10.
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