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Rolofylline

CAS No. 136199-02-5

Rolofylline( KW-3902 | KW3902 )

Catalog No. M11492 CAS No. 136199-02-5

A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rolofylline
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
  • Description
    A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM; displays 290-fold selectivity over A2AR; antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).Heart Failure Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KW-3902 | KW3902
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136199-02-5
  • Formula Weight
    356.46
  • Molecular Formula
    C20H28N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (56.11 mM)
  • SMILES
    O=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O
  • Chemical Name
    8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6. 2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.
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