Rolofylline

Research use only, not for human use.

A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.

A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM; displays 290-fold selectivity over A2AR; antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).Heart Failure Phase 3 Discontinued.

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KW-3902 | KW3902

Apoptosis

Adenosine Receptor

Adenosine Receptor

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136199-02-5

356.46

C20H28N4O2

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (56.11 mM)

O=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O

8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

(-20℃)

With Ice Pack

≥ 2 years