Cart
sales@molnova.com
Home - Products - Apoptosis - Adenosine Receptor - Rolofylline

Rolofylline

CAS No. 136199-02-5

Rolofylline( KW-3902 | KW3902 )

Catalog No. M11492 CAS No. 136199-02-5

A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Rolofylline
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
  • Description
    A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM; displays 290-fold selectivity over A2AR; antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).Heart Failure Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KW-3902 | KW3902
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136199-02-5
  • Formula Weight
    356.46
  • Molecular Formula
    C20H28N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (56.11 mM)
  • SMILES
    O=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O
  • Chemical Name
    8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6. 2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • SCH 442416

    SCH-442416 is an selective antagonist of adenosine A2A receptor.?SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.

  • ST-4206

    A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.

  • ST-1535

    A potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.

Sign In Join Free