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ZM-241385
CAS No. 139180-30-6
ZM-241385( ZM-241385 | ZM 241385 )
Catalog No. M11625 CAS No. 139180-30-6
ZM-241385 is a potent, non-xanthine A2A selective adenosine receptor antagonist with rat PC12 binding pIC50 of 9.52.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 221 | In Stock |
|
| 100MG | 410 | In Stock |
|
| 200MG | 618 | In Stock |
|
| 500MG | 972 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZM-241385
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NoteResearch use only, not for human use.
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Brief DescriptionZM-241385 is a potent, non-xanthine A2A selective adenosine receptor antagonist with rat PC12 binding pIC50 of 9.52.
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DescriptionZM-241385 is a potent, non-xanthine A2A selective adenosine receptor antagonist with rat PC12 binding pIC50 of 9.52; shows low affinity for A3 (pIC50=3.82); antagonizes vasodilatation of the coronary bed produced by 2-CADO and CGS21680 with pA2 of 8.57 and 9.02, respectively, in guinea-pig isolated Langendorff hearts; selectively attenuates the mean arterial blood pressure response produced by exogenous adenosine in conscious spontaneously hypertensive rats (3-10 mg/kg, p.o.).
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In VitroZM241385 (1 μM; 24-48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA and protein levels. RT-PCR Cell Line:PC12 cells Concentration:1 μM Incubation Time:24 hours Result:Suppressed the increased A2AR mRNA levels engendered by CGS21680.Western Blot Analysis Cell Line:PC12 cells Concentration:1 μM Incubation Time:48 hours Result:Decreased A2AR protein levels
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In VivoZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC. Animal Model:Female C57BL/6 WT mice received 4-nitroquinoline-N-oxide Dosage:0.2 μg/mouse, 0.4 μg/mouse Administration:Intraperitoneal injection; every day; for 11 weeks Result:Decreased tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC.
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SynonymsZM-241385 | ZM 241385
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorA2A
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number139180-30-6
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Formula Weight337.336
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Molecular FormulaC16H15N7O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESOC1=CC=C(CCNC2=NC3=NC(C4=CC=CO4)=NN3C(N)=N2)C=C1
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Chemical NamePhenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Poucher SM, et al. Br J Pharmacol. 1995 Jul;115(6):1096-102.
2. Guo D, et al. ChemMedChem. 2014 Apr;9(4):752-61.
3. Poucher SM, et al. J Pharm Pharmacol. 1996 Jun;48(6):601-6.
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