Rolipram
CAS No. 61413-54-5
Rolipram ( SB95952;ZK62711;(R,S)-Rolipram;SB 95952;ZK 62711;SB-95952;ZK-62711 )
Catalog No. M15314 CAS No. 61413-54-5
A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 39 | Get Quote |
|
50MG | 55 | Get Quote |
|
100MG | 78 | Get Quote |
|
200MG | 115 | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameRolipram
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
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DescriptionA potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively; increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM; inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.Asthma Phase 2 Clinical
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SynonymsSB95952;ZK62711;(R,S)-Rolipram;SB 95952;ZK 62711;SB-95952;ZK-62711
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE4B;PDE4D
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number61413-54-5
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Formula Weight275.34
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Molecular FormulaC16H21NO3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 41 mg/mL
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SMILESO=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
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Chemical Name2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8.
2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.
3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.
3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
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