Roflumilast ( B 9302-107; BY 217; BYK 20869; Daxas )

Catalog No. M12400 CAS No. 162401-32-3

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Product Name

Roflumilast
Note

Research use only, not for human use.
Brief Description

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor.
Description

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations. Treatment with Roflumilast is associated with an increase in psychiatric adverse reactions, including suicide and suicidal attempts.
Synonyms

B 9302-107; BY 217; BYK 20869; Daxas
Pathway

Angiogenesis
Target

PDE
Recptor

PDE4A1; PDE4A4; PDE4B1; PDE4B2; PDE4C1
Research Area

Inflammation/Immunology
Indication

——

CAS Number

162401-32-3
Formula Weight

403.21
Molecular Formula

C17H14Cl2F2N2O3
Purity

>98%(HPLC)
Solubility

Ethanol: 15 mg/mL (37.2 mM); DMSO: 81 mg/mL (200.88 mM)
SMILES

O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(OCC3CC3)=C2
Chemical Name

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

1.Barone FC, et al. Pharmacology. 2007 Aug 28;81(1):11-17.

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