Rolapitant

CAS No. 552292-08-7

Rolapitant ( SCH619734 )

Catalog No. M17539 CAS No. 552292-08-7

Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 54 In Stock
5MG 77 In Stock
10MG 113 In Stock
25MG 178 In Stock
50MG 295 In Stock
100MG 441 In Stock
500MG 981 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Rolapitant
  • Note
    Research use only, not for human use.
  • Brief Description
    Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.
  • Description
    Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
  • Synonyms
    SCH619734
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NK1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    552292-08-7
  • Formula Weight
    500.48
  • Molecular Formula
    C25H26F6N2O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 30 mg/mL; 59.94 mM
  • SMILES
    C[C@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rapoport B, et al. Eur J Y. 2016 Apr;57:23-30.
molnova catalog
related products
  • CFT7455

    CFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3).

  • 4-O-Feruloylquinic a...

    4-O-Feruloylquinic acid can be useful for the prevention of cardiovascular and other chronic diseases.

  • 1,4-Dihydroxy-2-carb...

    1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.