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Rolapitant
CAS No. 552292-08-7
Rolapitant ( SCH619734 )
Catalog No. M17539 CAS No. 552292-08-7
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.
Purity : 98%
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Size | Price / USD | Stock | Quantity |
2MG | 54 | In Stock |
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5MG | 77 | In Stock |
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10MG | 113 | In Stock |
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25MG | 178 | In Stock |
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50MG | 295 | In Stock |
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100MG | 441 | In Stock |
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500MG | 981 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameRolapitant
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NoteResearch use only, not for human use.
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Brief DescriptionRolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.
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DescriptionRolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
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SynonymsSCH619734
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PathwayOthers
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TargetOther Targets
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RecptorNK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number552292-08-7
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Formula Weight500.48
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Molecular FormulaC25H26F6N2O2
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Purity98%
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SolubilityDMSO : ≥ 30 mg/mL; 59.94 mM
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SMILESC[C@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rapoport B, et al. Eur J Y. 2016 Apr;57:23-30.
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