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Home - Products - Angiogenesis - CDK - Riviciclib

Riviciclib

CAS No. 920113-03-7

Riviciclib ( P276-00 hydrochloride )

Catalog No. M16603 CAS No. 920113-03-7

A novel potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Riviciclib
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.
  • Description
    A novel potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively; weakly inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk6/cyclin D3 and Cdk7/cyclin H with IC50 of 0.2-3 uM; shows potent antiproliferative effects against various human cancer cell lines (IC50=200-800 nM); induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.Pancreatic Cancer Phase 2 Clinical
  • Synonyms
    P276-00 hydrochloride
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK1/CyclinB; CDK2/CyclinA; CDK4/CyclinD1; CDK6/CyclinD3; CDK9/CyclinT1
  • Research Area
    Cancer
  • Indication
    Pancreatic Cancer

Chemical Information

  • CAS Number
    920113-03-7
  • Formula Weight
    438.30
  • Molecular Formula
    C21H20ClNO5.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCC(C1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
  • Chemical Name
    2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Joshi KS, et al. Mol Cancer Ther. 2007 Mar;6(3):918-25.
2. Joshi KS, et al. Mol Cancer Ther. 2007 Mar;6(3):926-34.
3. Raje N, et al. Leukemia. 2009 May;23(5):961-70.
4. Rathos MJ, et al. J Transl Med. 2012 Aug 8;10:161.
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