
Rituximab
CAS No. 174722-31-7
Rituximab( —— )
Catalog No. M22141 CAS No. 174722-31-7
Rituximab anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 501 | In Stock |
![]() ![]() |
10MG | 731 | In Stock |
![]() ![]() |
25MG | 1071 | In Stock |
![]() ![]() |
100MG | Get Quote | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameRituximab
-
NoteResearch use only, not for human use.
-
Brief DescriptionRituximab anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM.
-
DescriptionRituximab anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM.
-
In VitroRituximab inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab induces high CDC killing of follicular lymphoma cells.
-
In VivoA single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorOther Targets
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number174722-31-7
-
Formula Weight148 kDa
-
Molecular Formula——
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Du J, et al. Structural basis for recognition of CD20 by therapeutic antibody Rituximab. J Biol Chem. 2007 May 18;282(20).
molnova catalog



related products
-
NRX-1933
NRX-1933 is a molecular glue and enhances the interaction between an oncogenic transcription factor, β-Catenin, and its cognate E3 ligase, SCFβ-TrCP.
-
4,2-Dihydroxy-4-meth...
4,2'-Dihydroxy-4'-methoxychalcone shows allergy-preventive effects.
-
Saponin C, from Liri...
Saponin C from Liriope muscari can be extracted from Liriope muscari, family Liliaceae.