Rifabutin

Research use only, not for human use.

A semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Bacterial Infection Approved(In Vitro):Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.

Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.

——

Ansamycin | LM-427

GPCR/G Protein

Antibacterial

Endoplasmin|HSP90|RNApolymerase

Infection

Bacterial Infection

72559-06-9

847.0047

C46H62N4O11

>98% (HPLC)

10 mM in DMSO

O=C1c2c(O)c(C)c3c(C4=O)c2C5=NC6(CCN(CC(C)C)CC6)NC5=C1NC(/C(C)=C/C=C/[C@@H]([C@H](O)[C@H]([C@@H](O)[C@H]([C@@H]([C@H](C)[C@@H](OC)/C=C/O[C@]4(O3)C)OC(C)=O)C)C)C)=O

Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19

(-20℃)

With Ice Pack

≥ 2 years