
Rebamipide
CAS No. 90098-04-7
Rebamipide( OPC 12759 )
Catalog No. M16479 CAS No. 90098-04-7
Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
500MG | 41 | In Stock |
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1G | 49 | In Stock |
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Biological Information
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Product NameRebamipide
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NoteResearch use only, not for human use.
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Brief DescriptionRebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis.
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DescriptionRebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.
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In VitroCell Proliferation Assay Cell Line:AGS cells Concentration:1.4, 2.7, 5.4 mM Incubation Time:24 h Result:Significant decreased in cell proliferation in a concentration-dependent manner.Western Blot Analysis Cell Line:AGS cells Concentration:5.4 mM Incubation Time:30 min or 3 h Result:Significantly increased phosphorylation of Smad2/3 by 1.2-fold when at 30 min and formation of Smad2/3-Smad4 complex by 1.4-fold.Upregulated expression of p21 protein by 2.5-fold when at 3 h.
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In VivoAnimal Model:Specific pathogen-free male Sprague-Dawley rats (200-230 g; 7-week-old).Dosage:5, 15, 50 mg/kg Administration:Oral administration; once daily for 14 days.Result:Increased the level of COX-2 immunoreactivity and PGE2 in a dose-dependent manner. (PGE2 is implicated in protection of gastric mucosa from various insults and acceleration of gastric wound healing).Inhibited intragastric HCl administration-induced gastric mucosal bleeding and erosion.
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SynonymsOPC 12759
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PathwayNF-κB
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TargetFree radical scavengers
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RecptorFree radical scavengers
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number90098-04-7
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Formula Weight370.79
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Molecular FormulaC19H15ClN2O4
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Purity>98% (HPLC)
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SolubilityDMSO: 74 mg/mL (199.57 mM)
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SMILESO=C(O)C(NC(C1=CC=C(Cl)C=C1)=O)CC2=CC(NC3=C2C=CC=C3)=O
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Chemical Name2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Matsuda T, et al. Drugs R D. 2003;4(1):19-28.
molnova catalog



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