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Rebamipide

CAS No. 90098-04-7

Rebamipide( OPC 12759 )

Catalog No. M16479 CAS No. 90098-04-7

Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rebamipide
  • Note
    Research use only, not for human use.
  • Brief Description
    Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis.
  • Description
    Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.
  • In Vitro
    Cell Proliferation Assay Cell Line:AGS cells Concentration:1.4, 2.7, 5.4 mM Incubation Time:24 h Result:Significant decreased in cell proliferation in a concentration-dependent manner.Western Blot Analysis Cell Line:AGS cells Concentration:5.4 mM Incubation Time:30 min or 3 h Result:Significantly increased phosphorylation of Smad2/3 by 1.2-fold when at 30 min and formation of Smad2/3-Smad4 complex by 1.4-fold.Upregulated expression of p21 protein by 2.5-fold when at 3 h.
  • In Vivo
    Animal Model:Specific pathogen-free male Sprague-Dawley rats (200-230 g; 7-week-old).Dosage:5, 15, 50 mg/kg Administration:Oral administration; once daily for 14 days.Result:Increased the level of COX-2 immunoreactivity and PGE2 in a dose-dependent manner. (PGE2 is implicated in protection of gastric mucosa from various insults and acceleration of gastric wound healing).Inhibited intragastric HCl administration-induced gastric mucosal bleeding and erosion.
  • Synonyms
    OPC 12759
  • Pathway
    NF-κB
  • Target
    Free radical scavengers
  • Recptor
    Free radical scavengers
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    90098-04-7
  • Formula Weight
    370.79
  • Molecular Formula
    C19H15ClN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 74 mg/mL (199.57 mM)
  • SMILES
    O=C(O)C(NC(C1=CC=C(Cl)C=C1)=O)CC2=CC(NC3=C2C=CC=C3)=O
  • Chemical Name
    2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Matsuda T, et al. Drugs R D. 2003;4(1):19-28.
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