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Razuprotafib
CAS No. 1008510-37-9
Razuprotafib ( AKB-9778 )
Catalog No. M21740 CAS No. 1008510-37-9
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 484 | In Stock |
|
| 10MG | 700 | In Stock |
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| 25MG | 1062 | In Stock |
|
| 50MG | 1458 | In Stock |
|
| 100MG | 1962 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRazuprotafib
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NoteResearch use only, not for human use.
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Brief DescriptionRazuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM.
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DescriptionRazuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM).
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SynonymsAKB-9778
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1008510-37-9
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Formula Weight586.7
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Molecular FormulaC26H26N4O6S3
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (170.44 mM; Need ultrasonic)
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SMILESO=C([C@@H](NC(OC)=O)CC1=CC=CC=C1)N[C@H](C2=CSC(C3=CC=CS3)=N2)CC4=CC=C(NS(=O)(O)=O)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shen J, et al. Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J Clin Invest. 2014;124(10):4564-4576.
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