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Rapanone
CAS No. 573-40-0
Rapanone( 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione | 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone )
Catalog No. M24565 CAS No. 573-40-0
Rapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 102 | In Stock |
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| 10MG | 149 | In Stock |
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| 25MG | 251 | In Stock |
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| 50MG | 377 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRapanone
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NoteResearch use only, not for human use.
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Brief DescriptionRapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
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DescriptionRapanone is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
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In VitroRapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively.Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells.Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction.
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In VivoRapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice.
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Synonyms2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione | 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPLA2
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Research Area——
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Indication——
Chemical Information
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CAS Number573-40-0
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Formula Weight322.44
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Molecular FormulaC19H30O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (77.53 mM)
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SMILESCCCCCCCCCCCCCC(C(C(O)=CC1=O)=O)=C1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Andreu G , Reis F , M González-Durruthy, et al. Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death[J]. Toxicology in Vitro, 2019, 63(2016):104737.
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