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Raltegravir
CAS No. 518048-05-0
Raltegravir ( MK-0518;MK 0518;MK0518 )
Catalog No. M14807 CAS No. 518048-05-0
A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 95 | In Stock |
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| 25MG | 173 | In Stock |
|
| 50MG | 286 | In Stock |
|
| 100MG | 426 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRaltegravir
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.
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DescriptionA potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM; essentially inactive (IC50s>50 uM) against HCV Pol, HIV RT, HIV RNase-H, and human α/β/γ Pol; shows inhibitory activity against the wild type virus and a selection of mutants; the first HIV-integrase inhibitor for the treatment of HIV-1 infection.HIV Infection Approved
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SynonymsMK-0518;MK 0518;MK0518
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorIntegrase(S217QPFV);Integrase(WTPFV)
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number518048-05-0
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Formula Weight444.42
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Molecular FormulaC20H21FN6O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F
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Chemical Name4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Summa V, et al. J Med Chem. 2008 Sep 25;51(18):5843-55.
2. Malet I, et al. Antimicrob Agents Chemother. 2008 Apr;52(4):1351-8.
3. Cooper DA, et al. N Engl J Med. 2008 Jul 24;359(4):355-65.
2. Malet I, et al. Antimicrob Agents Chemother. 2008 Apr;52(4):1351-8.
3. Cooper DA, et al. N Engl J Med. 2008 Jul 24;359(4):355-65.
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