Ralaniten ( EPI-506 )

Catalog No. M10744 CAS No. 1203490-23-6

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Product Name

Ralaniten
Note

Research use only, not for human use.
Brief Description

Ralaniten (EPI-506) is a novel small-molecule inhibitor of androgen receptor (AR) N-terminal domain inhibitor for the treatment of advanced prostate cancer.
Description

Ralaniten (EPI-506) is a novel small-molecule inhibitor of androgen receptor (AR) N-terminal domain inhibitor for the treatment of advanced prostate cancer; AR NTD-targeting agents have the potential to overcome shortcomings of current hormonal therapies by inhibiting all forms of AR-mediated transcriptional activity, and as a result, may affect a broader AR population including mutational and splice variant ARs.Prostate Cancer Phase 2 Clinical
Synonyms

EPI-506
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

Estrogen Receptor/ERR
Research Area

Cancer
Indication

Prostate Cancer

CAS Number

1203490-23-6
Formula Weight

394.89
Molecular Formula

C21H27ClO5
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)(C1=CC=C(C=C1)OCC(CO)O)C2=CC=C(C=C2)OCC(CCl)O
Chemical Name

(2R)-3-[4-(2-{4-[(2S)-3-chloro- 2-hydroxypropoxy]phenyl}propan-2-yl)phenoxy]propane- 1,2-diol

1. Antonarakis ES, et al. Oncologist. 2016 Dec;21(12):1427-1435.

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