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GDC-0927

CAS No. 1642297-01-5

GDC-0927( GDC0927 | SRN-927 | RG-6047 )

Catalog No. M12490 CAS No. 1642297-01-5

GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GDC-0927
  • Note
    Research use only, not for human use.
  • Brief Description
    GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
  • Description
    GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.Breast Cancer Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    GDC-0927 is a novel, potent, non-steroidal, orally bioavailable, selective ER antagonist/ER degrader (SERD) that induces tumor regression in estrogen receptor (ER)+breast cancer (BC) patient-derived xenograft models.
  • Synonyms
    GDC0927 | SRN-927 | RG-6047
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen Receptor/ERR
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1642297-01-5
  • Formula Weight
    461.533
  • Molecular Formula
    C28H28FNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 216.68 mM
  • SMILES
    CC1=C(C(OC2=C1C=C(C=C2)O)C3=CC=C(C=C3)OCCN4CC(C4)CF)C5=CC(=CC=C5)O
  • Chemical Name
    (S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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