GDC-0927

CAS No. 1642297-01-5

GDC-0927( GDC0927 | SRN-927 | RG-6047 )

Catalog No. M12490 CAS No. 1642297-01-5

GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 672 Get Quote
25MG 1449 Get Quote
50MG 2313 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    GDC-0927
  • Note
    Research use only, not for human use.
  • Brief Description
    GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
  • Description
    GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.Breast Cancer Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    GDC-0927 is a novel, potent, non-steroidal, orally bioavailable, selective ER antagonist/ER degrader (SERD) that induces tumor regression in estrogen receptor (ER)+breast cancer (BC) patient-derived xenograft models.
  • Synonyms
    GDC0927 | SRN-927 | RG-6047
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen Receptor/ERR
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1642297-01-5
  • Formula Weight
    461.533
  • Molecular Formula
    C28H28FNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 216.68 mM
  • SMILES
    CC1=C(C(OC2=C1C=C(C=C2)O)C3=CC=C(C=C3)OCCN4CC(C4)CF)C5=CC(=CC=C5)O
  • Chemical Name
    (S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
related products
  • Promestriene

    Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation.

  • SLU-PP-332

    SLU-PP-332 is a pan-estrogen receptor-related receptor (ERR) agonist with high affinity for ERRα, ERRβ, and ERRγ, exhibiting EC50 values of 98, 230, and 430 nM, respectively.

  • Piceatannol 3'-O-glu...

    Piceatannol 3'-O-glucoside increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.