Cart
sales@molnova.com
GDC-0927
CAS No. 1642297-01-5
GDC-0927( GDC0927 | SRN-927 | RG-6047 )
Catalog No. M12490 CAS No. 1642297-01-5
GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 672 | Get Quote |
|
| 25MG | 1449 | Get Quote |
|
| 50MG | 2313 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGDC-0927
-
NoteResearch use only, not for human use.
-
Brief DescriptionGDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
-
DescriptionGDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.Breast Cancer Phase 1 Clinical.
-
In Vitro——
-
In VivoGDC-0927 is a novel, potent, non-steroidal, orally bioavailable, selective ER antagonist/ER degrader (SERD) that induces tumor regression in estrogen receptor (ER)+breast cancer (BC) patient-derived xenograft models.
-
SynonymsGDC0927 | SRN-927 | RG-6047
-
PathwayEndocrinology/Hormones
-
TargetEstrogen Receptor/ERR
-
RecptorEstrogen Receptor/ERR
-
Research AreaCancer
-
IndicationBreast Cancer
Chemical Information
-
CAS Number1642297-01-5
-
Formula Weight461.533
-
Molecular FormulaC28H28FNO4
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 100 mg/mL 216.68 mM
-
SMILESCC1=C(C(OC2=C1C=C(C=C2)O)C3=CC=C(C=C3)OCCN4CC(C4)CF)C5=CC(=CC=C5)O
-
Chemical Name(S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
XCT790
A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
-
Aquacrine
Estrone is an estrogenic hormone.
-
Endoxifen
A metabolite of tamoxifen, orally active non-steroidal selective estrogen receptor modulator (SERM) for the treatment of estrogen receptor-positive breast cancer.
