RVX2135 ( RVX 2135 )

Catalog No. M11020 CAS No. 1253733-17-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

RVX2135
Note

Research use only, not for human use.
Brief Description

RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT.
Description

RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively; blocks proliferation of Myc-induced mouse lymphoma cells and induces Caspase-dependent apoptosis; exhibits broad transcriptional effects in Myc-transgenic lymphoma cells affecting many transcription factor networks.
Synonyms

RVX 2135
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1253733-17-3
Formula Weight

411.50
Molecular Formula

C23H29N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(OCCNC(C)C)C(C)=CC(C2=NC3=CC(OC)=CC(OC)=C3C(N2)=O)=C1
Chemical Name

2-(4-(2-(isopropylamino)ethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
2. Bhadury J, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2721-30.

Calculator

molnova catalog