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RUSKI-201

CAS No. 1458031-48-5

RUSKI-201( RUSKI 201 | RUSKI201 )

Catalog No. M11977 CAS No. 1458031-48-5

A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RUSKI-201
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
  • Description
    A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RUSKI 201 | RUSKI201
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Hedgehog (Hh)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1458031-48-5
  • Formula Weight
    357.516
  • Molecular Formula
    C20H27N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CC=CC(C2C(C=CS3)=C3CCN2C(CNCC(C)CC)=O)=N1
  • Chemical Name
    1-[6,7-Dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]ethanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.
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