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RRX-001
CAS No. 925206-65-1
RRX-001 ( RRX001;RRX 001 )
Catalog No. M16629 CAS No. 925206-65-1
RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 63 | In Stock |
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| 5MG | 105 | In Stock |
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| 10MG | 140 | In Stock |
|
| 25MG | 264 | In Stock |
|
| 50MG | 462 | In Stock |
|
| 100MG | 673 | In Stock |
|
| 500MG | 1404 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRRX-001
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NoteResearch use only, not for human use.
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Brief DescriptionRRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity.
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DescriptionRRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity; targets CD133 + /CD44 + cancer stem cells from colon cancer cell-lines, HT-29, Caco-2, and HCT116, and inhibits Wnt pathway signalling with downregulation of c-Myc; inhibits HCT 116 and decreases levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner; RRX-001 (RRX001) is a chemosensitizer in multiple tumor types and disease states including malaria, hemorrhagic shock and sickle cell anemia.Lung Cancer Phase 2 Clinical
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SynonymsRRX001;RRX 001
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number925206-65-1
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Formula Weight268.02
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Molecular FormulaC5H6BrN3O5
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 373.11 mM
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SMILESO=[N+](C1([N+]([O-])=O)CN(C(CBr)=O)C1)[O-]
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Chemical Name2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Reid T, et al. Lancet Oncol. 2015 Sep;16(9):1133-1142. doi: 10.1016/S1470-2045(15)00089-3.
2. Scicinski J, et al. Redox Biol. 2015 Aug;5:422. doi: 10.1016/j.redox.2015.09.035.
3. Kim MM, et al. Transl Oncol. 2016 Apr;9(2):108-113.
4. Oronsky B, et al. Invest New Drugs. 2016 Jun;34(3):371-7.
2. Scicinski J, et al. Redox Biol. 2015 Aug;5:422. doi: 10.1016/j.redox.2015.09.035.
3. Kim MM, et al. Transl Oncol. 2016 Apr;9(2):108-113.
4. Oronsky B, et al. Invest New Drugs. 2016 Jun;34(3):371-7.
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