RRX-001

CAS No. 925206-65-1

RRX-001 ( RRX001;RRX 001 )

Catalog No. M16629 CAS No. 925206-65-1

RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 63 In Stock
5MG 105 In Stock
10MG 140 In Stock
25MG 264 In Stock
50MG 462 In Stock
100MG 673 In Stock
500MG 1404 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    RRX-001
  • Note
    Research use only, not for human use.
  • Brief Description
    RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity.
  • Description
    RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity; targets CD133 + /CD44 + cancer stem cells from colon cancer cell-lines, HT-29, Caco-2, and HCT116, and inhibits Wnt pathway signalling with downregulation of c-Myc; inhibits HCT 116 and decreases levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner; RRX-001 (RRX001) is a chemosensitizer in multiple tumor types and disease states including malaria, hemorrhagic shock and sickle cell anemia.Lung Cancer Phase 2 Clinical
  • Synonyms
    RRX001;RRX 001
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    925206-65-1
  • Formula Weight
    268.02
  • Molecular Formula
    C5H6BrN3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 373.11 mM
  • SMILES
    O=[N+](C1([N+]([O-])=O)CN(C(CBr)=O)C1)[O-]
  • Chemical Name
    2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Reid T, et al. Lancet Oncol. 2015 Sep;16(9):1133-1142. doi: 10.1016/S1470-2045(15)00089-3.
2. Scicinski J, et al. Redox Biol. 2015 Aug;5:422. doi: 10.1016/j.redox.2015.09.035.
3. Kim MM, et al. Transl Oncol. 2016 Apr;9(2):108-113.
4. Oronsky B, et al. Invest New Drugs. 2016 Jun;34(3):371-7.
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