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RO9021
CAS No. 1446790-62-0
RO9021( —— )
Catalog No. M23611 CAS No. 1446790-62-0
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 215 | In Stock |
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| 10MG | 327 | In Stock |
|
| 25MG | 552 | In Stock |
|
| 50MG | 786 | In Stock |
|
| 100MG | 1062 | In Stock |
|
| 500MG | 2142 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRO9021
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NoteResearch use only, not for human use.
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Brief DescriptionRO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
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DescriptionRO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
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In VitroRO9021 is a highly selective SYK inhibitor with low S-scores of 0.003 for S(99) and 0.015 for S(90), indicating that SYK is the only kinase with 99% competition with RO9021 in a total of 392 tested kinases. RO9021 inhibits anti-IgM induced phosphorylation of BTK, PLCγ2, AKT and ERK, indicating that blockade of SYK kinase activity by RO9021 results in attenuation of BCR downstream signaling cascade. RO9021 selectively suppresses B-cell receptor signaling. RO9021 also displays a similar inhibitory potency (IC50=22.8±1.7 nM) in a FcεR-mediated mast cell activation and degranulation assay.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetSyk
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RecptorSYK
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Research Area——
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Indication——
Chemical Information
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CAS Number1446790-62-0
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Formula Weight355.44
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Molecular FormulaC18H25N7O
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Purity>98% (HPLC)
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SolubilityDMSO:3 mg/mL (8.44 mM; Need ultrasonic)
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SMILESCc(cc1)c(C)nc1Nc1cc(N[C@H](CCCC2)[C@H]2N)nnc1C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Liao C, et al. Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.
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