RO-5353( RO5353 | RO 5353 )

Catalog No. M11486 CAS No. 1360821-61-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

RO-5353
Note

Research use only, not for human use.
Brief Description

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.
Description

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.
In Vitro

——
In Vivo

——
Synonyms

RO5353 | RO 5353
Pathway

Apoptosis
Target

MDM2-p53
Recptor

MDM2-p53
Research Area

——
Indication

——

CAS Number

1360821-61-9
Formula Weight

619.533
Molecular Formula

C29H29Cl2FN4O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(S5)Cl)NC2=O
Chemical Name

(2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.

Calculator

molnova catalog