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Home - Products - Apoptosis - MDM2-p53 - RO-5353

RO-5353

CAS No. 1360821-61-9

RO-5353( RO5353 | RO 5353 )

Catalog No. M11486 CAS No. 1360821-61-9

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RO-5353
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.
  • Description
    A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RO5353 | RO 5353
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1360821-61-9
  • Formula Weight
    619.533
  • Molecular Formula
    C29H29Cl2FN4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(S5)Cl)NC2=O
  • Chemical Name
    (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.
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