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RN9893

CAS No. 1803003-68-0

RN9893( —— )

Catalog No. M34399 CAS No. 1803003-68-0

RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RN9893
  • Note
    Research use only, not for human use.
  • Brief Description
    RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.
  • Description
    RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1803003-68-0
  • Formula Weight
    500.49
  • Molecular Formula
    C21H23F3N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (499.51 mM; Ultrasonic )
  • SMILES
    C(NC1=CC=C(S(=O)(=O)N2CCN(C(C)C)CC2)C=C1)(=O)C3=C(N(=O)=O)C=C(C(F)(F)F)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wei ZL, et, al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.?
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