Home - Products - Microbiology/Virology - HIV - RN-18

RN-18

CAS No. 431980-38-0

RN-18 ( Vif inhibitor RN-18 )

Catalog No. M14465 CAS No. 431980-38-0

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	80	Get Quote
10MG	135	Get Quote
25MG	299	Get Quote
50MG	507	Get Quote
100MG	714	Get Quote
500MG	1503	Get Quote
1G	Get Quote	Get Quote

Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

RN-18
Note

Research use only, not for human use.
Brief Description

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G.
Description

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G; increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation; enhances Vif degradation, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.
Synonyms

Vif inhibitor RN-18
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

Infection
Indication

——

Chemical Information

CAS Number

431980-38-0
Formula Weight

380.42
Molecular Formula

C20H16N2O4S
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 262.87 mM; H2O : < 0.1 mg/mL
SMILES

COC1=CC=CC=C1NC(=O)C2=CC=CC=C2SC3=CC=C(C=C3)[N+](=O)[O-]
Chemical Name

N-(2-Methoxyphenyl)-2-[(4-nitrophenyl)thio]benzamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Nathans R, et al. Nat Biotechnol. 2008 Oct;26(10):1187-92.
2. Mohammed I, et al. J Med Chem. 2016 Aug 25;59(16):7677-82.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

Efavirenz

A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.
Rilpivirine

A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay.
Terameprocol

Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.

Sign In Join Free