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RN-18

CAS No. 431980-38-0

RN-18 ( Vif inhibitor RN-18 )

Catalog No. M14465 CAS No. 431980-38-0

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RN-18
  • Note
    Research use only, not for human use.
  • Brief Description
    RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G.
  • Description
    RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G; increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation; enhances Vif degradation, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.
  • Synonyms
    Vif inhibitor RN-18
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    431980-38-0
  • Formula Weight
    380.42
  • Molecular Formula
    C20H16N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL 262.87 mM; H2O : < 0.1 mg/mL
  • SMILES
    COC1=CC=CC=C1NC(=O)C2=CC=CC=C2SC3=CC=C(C=C3)[N+](=O)[O-]
  • Chemical Name
    N-(2-Methoxyphenyl)-2-[(4-nitrophenyl)thio]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nathans R, et al. Nat Biotechnol. 2008 Oct;26(10):1187-92.
2. Mohammed I, et al. J Med Chem. 2016 Aug 25;59(16):7677-82.
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