RN-18

Research use only, not for human use.

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G.

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G; increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation; enhances Vif degradation, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.

Vif inhibitor RN-18

Microbiology/Virology

HIV

HIV

Infection

——

431980-38-0

380.42

C20H16N2O4S

>98% (HPLC)

DMSO : 100 mg/mL 262.87 mM; H2O : < 0.1 mg/mL

COC1=CC=CC=C1NC(=O)C2=CC=CC=C2SC3=CC=C(C=C3)[N+](=O)[O-]

N-(2-Methoxyphenyl)-2-[(4-nitrophenyl)thio]benzamide

(-20℃)

With Ice Pack

≥ 2 years