RIPK3-IN-1( —— )

Catalog No. M35728 CAS No. 2361139-70-8

RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumorigenic activity and can be used to study apoptosis.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

RIPK3-IN-1
Note

Research use only, not for human use.
Brief Description

RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumorigenic activity and can be used to study apoptosis.
Description

RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis | RIP kinase | c-Met/HGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

2361139-70-8
Formula Weight

512.53
Molecular Formula

C29H25FN4O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 5 mg/mL (9.76 mM; Ultrasonic (<80°C)
SMILES

Cc1c(C)c(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)c1cccn(-c2ccc(F)cc2)c1=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Amy C Hart, et al. Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage. ACS Med Chem Lett. 2019 May 6;11(3):266-271.?

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