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RIPK3-IN-1
CAS No. 2361139-70-8
RIPK3-IN-1( —— )
Catalog No. M35728 CAS No. 2361139-70-8
RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumorigenic activity and can be used to study apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 108 | Get Quote |
|
| 5MG | 163 | Get Quote |
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| 10MG | 275 | Get Quote |
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| 25MG | 540 | Get Quote |
|
| 50MG | 877 | Get Quote |
|
| 100MG | 1368 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRIPK3-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionRIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumorigenic activity and can be used to study apoptosis.
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DescriptionRIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | RIP kinase | c-Met/HGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number2361139-70-8
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Formula Weight512.53
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Molecular FormulaC29H25FN4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (9.76 mM; Ultrasonic (<80°C)
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SMILESCc1c(C)c(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)c1cccn(-c2ccc(F)cc2)c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Amy C Hart, et al. Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage. ACS Med Chem Lett. 2019 May 6;11(3):266-271.?
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