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REDX-05358
CAS No. 1884226-20-3
REDX-05358( REDX 05358 | REDX05358 )
Catalog No. M12942 CAS No. 1884226-20-3
REDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameREDX-05358
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NoteResearch use only, not for human use.
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Brief DescriptionREDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor.
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DescriptionREDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively; denmonstrates high selectivity profile against a panel of 468 kinases, exhibits negligible paradoxical activation due to inhibition of both RAF monomers and dimers; not only inhibits MAPK signalling in BRAF V600E mutant tumor cells, but also in those harbouring NRAS and KRAS mutations; exhibits in vivo efficacy in BRAF V600E CRC xenograft model.
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In Vitro——
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In Vivo——
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SynonymsREDX 05358 | REDX05358
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorRaf
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Research Area——
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Indication——
Chemical Information
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CAS Number1884226-20-3
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Formula Weight472.929
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Molecular FormulaC26H21ClN4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : < 0.1 mg/mL (insoluble))
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SMILESO=C(CC1)NC2=C1C(OC3=CC(CC(C4=NC=C(C5=CC=CC=C5Cl)N4)CO6)=C6C=C3)=CC=N2
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Chemical Name5-[[3-[5-(2-Chlorophenyl)-1H-imidazol-2-yl]chroman-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Helen Mason, et al. AACR, Abstract 5160.
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