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EBI-907
CAS No. 1581764-31-9
EBI-907( EBI907 )
Catalog No. M12260 CAS No. 1581764-31-9
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1323 | Get Quote |
|
| 50MG | 2682 | Get Quote |
|
| 100MG | 3600 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameEBI-907
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NoteResearch use only, not for human use.
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Brief DescriptionEBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.
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DescriptionEBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM; shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines; demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse.
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In Vitro——
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In Vivo——
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SynonymsEBI907
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorRaf
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Research Area——
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Indication——
Chemical Information
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CAS Number1581764-31-9
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Formula Weight506.95
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Molecular FormulaC23H21ClF2N4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=CC2=C(C=C1C3=C(F)C=CC(NS(CCCF)(=O)=O)=C3Cl)C=NC4=C2C(C5CC5)=NN4
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Chemical NameN-(2-chloro-3-(1-cyclopropyl-8-methoxy-3H-pyrazolo[3,4-c]isoquinolin-7-yl)-4-fluorophenyl)-3-fluoropropane-1-sulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu B, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-23.
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