R-7050 ( R-7050; R 7050; R7050; TNF-α Antagonist III )

Catalog No. M18394 CAS No. 303997-35-5

R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

Purity : 98%

COA

Datasheet

HNMR

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MSDS

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Size	Price / USD	Stock	Quantity
2MG	34	In Stock
5MG	55	In Stock
10MG	87	In Stock
25MG	195	In Stock
50MG	267	In Stock
100MG	439	In Stock
500MG	954	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

R-7050
Note

Research use only, not for human use.
Brief Description

R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
Description

R-7050 is a TNF-α receptor antagonist. It acts by blocking receptor-adaptor molecule complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding.
Synonyms

R-7050; R 7050; R7050; TNF-α Antagonist III
Pathway

Others
Target

Other Targets
Recptor

TNF-α
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

303997-35-5
Formula Weight

380.77
Molecular Formula

C16H8ClF3N4S
Purity

98%
Solubility

DMSO : 25 mg/mL 65.66 mM;
SMILES

FC(F)(F)c3nnc2c(nc1ccc(Cl)cc1n23)Sc4ccccc4
Chemical Name

8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Gururaja TL, et al. A class of small molecules that inhibit TNFalpha-induced survival and death pathways viaprevention of interactions between TNFalphaRI, TRADD, and RIP1. Chem Biol. 2007 Oct;14(10):1105-18.

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