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Quinupramine
CAS No. 31721-17-2
Quinupramine( —— )
Catalog No. M35460 CAS No. 31721-17-2
Quinupramine (LM 208) is an orally available classical tricyclic antidepressant compound with a strong affinity for muscarinic and 5-HT receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 702 | Get Quote |
|
| 5MG | 1017 | Get Quote |
|
| 25MG | 1960 | Get Quote |
|
| 50MG | 2558 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameQuinupramine
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NoteResearch use only, not for human use.
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Brief DescriptionQuinupramine (LM 208) is an orally available classical tricyclic antidepressant compound with a strong affinity for muscarinic and 5-HT receptors.
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DescriptionQuinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system.
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In Vitro——
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In VivoQuinupramine (10 mg/kg, PO, twice daily for 10 days) causes a down-regulation of serotonin S2 receptors in the frontal cortex of the rat.Quinupramine-EVA matrix containing a permeation enhancer can be a good transdermal delivery system for providing sustained plasma concentrations.Animal Model:Sprague-Dawley rats (Male, 220-270 g)Dosage:10 mg/kg Administration:PO, twice daily for 10 days Result:Caused a down-requlation of serotonin S2 receptors in the frontal cortex of the rat, did not alter the binding populations of Q-adrenergic, muscarinic cholinergic and a2-adrenergic receptors in the rat brain.
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Synonyms——
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number31721-17-2
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Formula Weight304.43
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Molecular FormulaC21H24N2
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Purity>98% (HPLC)
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Solubility——
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SMILESC=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)C4CN5CCC4CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sakamoto H, et al. Effects of quinupramine on the central monoamine uptake systems and involvement of pharmacokinetics in its pharmacological activities. Jpn J Pharmacol. 1987;45(2):169-175.?
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