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Spiroxatrine
CAS No. 1054-88-2
Spiroxatrine( —— )
Catalog No. M33930 CAS No. 1054-88-2
Spiroxatrine (R 5188) is a selective and potent 5-HT1α and α2-adrenergic dual antagonist with sedative activity, and inhibitory effects on 5-HT1α, 5-HT1β, 5-HT2, and dopamine receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 76 | Get Quote |
|
| 10MG | 122 | Get Quote |
|
| 25MG | 242 | Get Quote |
|
| 50MG | 388 | Get Quote |
|
| 100MG | 552 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSpiroxatrine
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NoteResearch use only, not for human use.
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Brief DescriptionSpiroxatrine (R 5188) is a selective and potent 5-HT1α and α2-adrenergic dual antagonist with sedative activity, and inhibitory effects on 5-HT1α, 5-HT1β, 5-HT2, and dopamine receptors.
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DescriptionSpiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.
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In Vitro——
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In VivoAnimal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model Dosage:1, 10, 25 ug, 5 days Administration:Intraperitoneal injection (i.p.)Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats Dosage:4 mg/kg/day, 5 mins Administration:Intraperitoneal injection (i.p.)Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.
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Synonyms——
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor | Dopamine Receptor | Adrenergic Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1054-88-2
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Formula Weight379.45
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Molecular FormulaC22H25N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 1.92 mg/mL (5.06 mM; Ultrasonic (<60°C)
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SMILESO=C1C2(N(CN1)C3=CC=CC=C3)CCN(CC4OC=5C(OC4)=CC=CC5)CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. D L Nelson, et al. Spiroxatrine: a selective serotonin1A receptor antagonist. Eur J Pharmacol. 1986 May 13;124(1-2):207-8.?
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