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Quinidine

CAS No. 56-54-2

Quinidine( —— )

Catalog No. M21153 CAS No. 56-54-2

Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent.?for the treatment of abnormal heart rhythms and also malaria.

Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent.?for the treatment of abnormal heart rhythms and also malaria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Quinidine
  • Note
    Research use only, not for human use.
  • Brief Description
    Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent.?for the treatment of abnormal heart rhythms and also malaria.
  • Description
    Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent.?for the treatment of abnormal heart rhythms and also malaria.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:MES-SA and MESSA/DX5 cells Concentration:10 μM Incubation Time:24 hours Result:Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.Apoptosis Analysis Cell Line:MES-SA and MESSA/DX5 cells Concentration:10 μM Incubation Time:24 hours Result:Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
  • In Vivo
    Animal Model:Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5Dosage:10, 20, and 30 mg/kg Administration:Intraperitoneal injection; 10, 20, and 30 mg/kg; once Result:Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    Inflammation/Immunology
  • Indication
    Nonalcoholic Steatohepatitis

Chemical Information

  • CAS Number
    56-54-2
  • Formula Weight
    324.42
  • Molecular Formula
    C20H24N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (154.12 mM)
  • SMILES
    C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12
  • Chemical Name
    (S)-[(2R4S5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Salata J J Wasserstrom J A . Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes[J]. Circulation Research 1988 62(2):324-337.
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