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Quilseconazole

CAS No. 1340593-70-5

Quilseconazole ( VT-1129;VT1129 )

Catalog No. M11366 CAS No. 1340593-70-5

A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Quilseconazole
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor.
  • Description
    A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor; displays greater selectivity for fungal enzyme than for mammalian CYP450 compared to the approved azole class of antifungal drugs; inhibits C. albicans and T. rubrum with MIC of <0.001 ug/mL, also demonstrated potent activities against Cryptococcusspecies as demonstrated by low MIC50 and MIC90 values.
  • Synonyms
    VT-1129;VT1129
  • Pathway
    Microbiology/Virology
  • Target
    Fungal
  • Recptor
    Fungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1340593-70-5
  • Formula Weight
    513.38
  • Molecular Formula
    C22H14F7N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O[C@@](CN1N=NN=C1)(C2=CC=C(F)C=C2F)C(F)(F)C3=NC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C3
  • Chemical Name
    (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(trifluoromethoxy)phenyl]pyridin-2-yl}propan-2-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hoekstra WJ, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8.
2. Lockhart SR, et al. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31.
3. Warrilow AG, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8.
4. Nielsen K, et al. Med Mycol. 2017 Jun 1;55(4):453-456.
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