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ML316
CAS No. 1604819-70-6
ML316( ML 316 )
Catalog No. M12305 CAS No. 1604819-70-6
ML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameML316
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NoteResearch use only, not for human use.
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Brief DescriptionML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1.
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DescriptionML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1, exhibits potent antifungal activity against the moderatelyazole-resistant C. albicans strain CaCi-2 with MIC of 0.05 ug/ml; kills drug-resistant Candida species at nanomolar concentrations; diminishes mitochondrial oxygen consumption, resulting in an unusual metabolic catastrophe marked by citrate accumulation and death in respiring yeast; reduces fungal burden and enhances azole activity in mouse model of azole-resistant oropharyngeal candidiasis.
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In Vitro——
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In Vivo——
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SynonymsML 316
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PathwayMicrobiology/Virology
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TargetFungal
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RecptorFungal
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Research Area——
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Indication——
Chemical Information
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CAS Number1604819-70-6
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Formula Weight350.408
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Molecular FormulaC17H19FN2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Nameethyl 1-(4-fluorophenyl)-4-oxo-2-thioxo-1,3-diazaspiro[4.5]decane-3-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McLellan CA, et al. Nat Chem Biol. 2018 Feb;14(2):135-141.
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