QCA570
CAS No. 2207569-08-0
QCA570 ( QCA 570;QCA-570 )
Catalog No. M13519 CAS No. 2207569-08-0
QCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameQCA570
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NoteResearch use only, not for human use.
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Brief DescriptionQCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level.
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DescriptionQCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level; inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively; causes complete and durable tumor regression in leukemia xenograft models in mice.
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SynonymsQCA 570;QCA-570
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2207569-08-0
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Formula Weight695.80
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Molecular FormulaC39H33N7O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C(N(CC1=C2C=CC=C1C#CCCCN3N=CC(C#CC(S4)=C(CC5=CC=CC=C5)C6=C4N7C(COC6)=NN=C7C)=C3)C2=O)CC8)NC8=O
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Chemical Name3-(4-(5-(4-((3-Benzyl-9-methyl-4H,6H-thieno[2,3-e][1,2,4]-triazolo[3,4-c][1,4]oxazepin-2-yl)ethynyl)-1H-pyrazol-1-yl)pent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Qin C, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00506.
molnova catalog
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