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QCA570

CAS No. 2207569-08-0

QCA570( QCA 570 | QCA-570 )

Catalog No. M13519 CAS No. 2207569-08-0

QCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    QCA570
  • Note
    Research use only, not for human use.
  • Brief Description
    QCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level.
  • Description
    QCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level; inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively; causes complete and durable tumor regression in leukemia xenograft models in mice.
  • In Vitro
    QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date.
  • In Vivo
    ——
  • Synonyms
    QCA 570 | QCA-570
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2207569-08-0
  • Formula Weight
    695.798
  • Molecular Formula
    C39H33N7O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 40 mg/mL (57.49 mM)
  • SMILES
    O=C(C(N(CC1=C2C=CC=C1C#CCCCN3N=CC(C#CC(S4)=C(CC5=CC=CC=C5)C6=C4N7C(COC6)=NN=C7C)=C3)C2=O)CC8)NC8=O
  • Chemical Name
    3-(4-(5-(4-((3-Benzyl-9-methyl-4H,6H-thieno[2,3-e][1,2,4]-triazolo[3,4-c][1,4]oxazepin-2-yl)ethynyl)-1H-pyrazol-1-yl)pent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Qin C, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00506.
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