Pyridaben

Research use only, not for human use.

Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).

Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).

Cell Viability Assay Cell Line:Rat brain submitochondrial particles Concentration:0-10 μM Incubation Time:3 min Result:Led to a decrease of NADH-cytochrome reductase activity (complex I-III) and without modification of succinate-cytochrome c reductase activity (complex II-III) and of cytochrome oxidase activity (complex IV)Cell Viability Assay Cell Line:Rat brain mitochondriaConcentration:0-10 μMIncubation Time:3 min Result:Showed a marked and dose-dependent decrease in respiratory control in the presence of malate-glutamate as substrate (IC50=1.7 μM)

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Others

Other Targets

NADH dehydrogenase(NADH:ubiquinone oxidoreductase|Electron transport complex I)

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96489-71-3

364.93

C19H25ClN2OS

>98% (HPLC)

DMSO: 50 mg/mL;Ethanol: 57 mg/mL;Water: Insoluble

CC(C)(C)c1ccc(CSc2cnn(c(=O)c2Cl)C(C)(C)C)cc1

2-(tert-butyl)-5-((4-(tert-butyl)benzyl)thio)-4-chloropyridazin-3(2H)-one

(-20℃)

With Ice Pack

≥ 2 years