Propargylcholine( Propargylcholine (bromide) )

Catalog No. M28160 CAS No. 111755-76-1

Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Propargylcholine
Note

Research use only, not for human use.
Brief Description

Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
Description

Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
In Vitro

Propargylcholine bromide (10, 50 μM; 24 h) incorporates into NIH 3T3 cells and shows strong staining in a concentration-dependent manner (fixed and stained with Alexa568-azide). Immunofluorescence Cell Line:NIH 3T3 cells Concentration:10, 50 μM Incubation Time:24 h Result:Showed strong staining proportional in intensity to the concentration of added Propargylcholine bromide.
In Vivo

Propargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) effectivelyincorporates into newly synthesized myelin within 1 week of dosing and sustained presence beyond 6 weeks in rhesus monkey.
Synonyms

Propargylcholine (bromide)
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Bacterial|PGE2|COX-1|E. coli
Research Area

——
Indication

——

Chemical Information

CAS Number

111755-76-1
Formula Weight

208.099
Molecular Formula

C7H14BrNO
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 125 mg/mL (600.67 mM)
SMILES

[Br-].C[N+](C)(CCO)CC#C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhou Yin,et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487.

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