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GSK1733953A

CAS No. 930470-97-6

GSK1733953A( —— )

Catalog No. M34269 CAS No. 930470-97-6

GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 ± 0.6 μM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

GSK1733953A
Note

Research use only, not for human use.
Brief Description

GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 ± 0.6 μM.
Description

DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research.
In Vitro

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In Vivo

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Synonyms

——
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

930470-97-6
Formula Weight

385.82
Molecular Formula

C21H17ClFNO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (259.19 mM; Ultrasonic )
SMILES

O(C)C1=C(C=C(NC(=O)C2=C(Cl)C=C(F)C=C2)C=C1)C3=CC=C(OC)C=C3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440. ?

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